Get Antiphospholipid Syndrome PDF

By A. Bulikova

ISBN-10: 9535105264

ISBN-13: 9789535105268

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The discovery of the native state of β2GPI as a circular protein explained the important paradox that antibodies and protein could circulate separately in blood. Also, other previously ascribed functions were probably functions of the protein induced by the harsh method of purification after which only the open, activated, conformation of the protein was obtained. Furthermore, the potential of antibodies, anionic phospholipids, LPS and probably even more agents to switch the conformation of β2GPI from a circular to an open activated conformation has given a clue to its role as scavenger, since the open conformation can bind to and subsequently be taken up by cells such as monocytes and macrophages.

Birdsall MA, Pattison NS & Chamley LW. (1992) Antiphospholipid antibodies in pregnancy. J Obstet Gynaecol. 32, 328-330. Blank M, Cohen J, Toder V & Shoenfeld Y. (1991) Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci U S A. 88(8), 3069-3073. Bouma B, de Groot PG, van den Elsen JM, Ravelli RB, Schouten A, Simmelink MJ, Derksen RH, Kroon J & Gros P. (1999) Adhesion mechanism of human beta(2)glycoprotein I to phospholipids based on its crystal structure.

Nicked beta2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis. Blood 103:3766-3772. A. 2006. An endogenous inhibitor of angiogenesis derived from a transitional cell carcinoma: clipped beta2glycoprotein-I. Ann Surg Oncol 13:1241-1251. J. 2007. Plasmincleaved beta-2-glycoprotein 1 is an inhibitor of angiogenesis. Am J Pathol 171:16591669. A. Plasmin-clipped beta(2)-glycoprotein-I inhibits endothelial cell growth by downregulating cyclin A, B and D1 and up-regulating p21 and p27.

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Antiphospholipid Syndrome by A. Bulikova


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