By Summer Research Institute on Algebraic Geometry, Spencer J. Bloch, C. Herbert Clemens
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Extra resources for Algebraic Geometry: Bowdoin, 1985, volume: 46 part 2 (Proceedings of Symposia in Pure Mathematics)
2005; Korotkova et al. 2003; Nakamura et al. 2000; Narita et al. 2006) (Hagan et al. 1999; Horvath et al. 1999; van den Pol et al. 2002) (Brown et al. 2001, 2002) (Burlet et al. 2002; Takakusaki et al. 2005; Xi et al. 2001) (van den Pol et al. 2002; Yamamoto et al. 2002) (Antunes et al. 2001; van den Top et al. 2003) Activation Pain and thermal sensation Heart rate, blood pressure Abbreviations: BF; basal forebrain, BST; bed nucleus stria terminalis, CM; central medial nucleus, PVT; paraventricular nucleus of the thalamus, Arc; arcuate nucleus, VMH; ventomedial nucleus, DMH; dorsomedial nucleus, LHA; lateral hypothalamic area, PFA; perifornical area, PVN; paraventricular nucleus, TMN; tuberomammillary nucleus of the hypothalamus, LC; locus coeruleus, VTA; vetral tegmental area, NAc; nucleus accumbens, LS; lateral septum, DR; dorsal raphe, LDT; laterodorsal tegmental nucleus, PPT; pedunculopontine nucleus, DRG; dorsal root ganglion, GABA; γ -aminobutyric acid, POMC; proopiomelanocortin, NPY; neuropeptide Y, MCH; melanin concentrating hormone, CRF; corticotropin-releasing factor, Glu; glutamate acetylcholine (Gallopin et al.
2002; Marcus et al. 2001). OX2 R is expressed in the amygdala and BST, PVT, DR, VTA, and LDT/PPT (Lu et al. 2002; Marcus et al. 2001). On the other hand, OX2 R is prominent in the Arc, TMN, DMH, paraventricular nucleus (PVN), LHA in the hypothalamus, CA3 in the hippocampus, and medial septal nucleus (Lu et al. 2002; Marcus et al. 2001). These histological ﬁndings suggest that orexins and their receptors are involved in feeding, sleep, memory, and reward systems. These regions are major effector sites of orexins, as later described in detail.
Consistently, prepro-orexin expression of normal and ob/ob mice is negatively correlated with changes in blood glucose, leptin, and food intake (Yamanaka et al. 2003a). 3 Mechanism of Orexin-mediated Feeding Supporting the physiological relevance of orexin in the control of feeding, icv administration of anti-orexin antibody or an OX1 R-selective antagonist reduced food intake (Haynes et al. 2000; Yamada et al. 2000). Prepro-orexin knockout mice and transgenic mice lacking orexin neurons ate less than control wild-type mice (Hara et al.
Algebraic Geometry: Bowdoin, 1985, volume: 46 part 2 (Proceedings of Symposia in Pure Mathematics) by Summer Research Institute on Algebraic Geometry, Spencer J. Bloch, C. Herbert Clemens