By Icon Health Publications
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Extra info for Aldosterone - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In other states of noninflammatory nephron deficit, compensatory single-nephron hyperfiltration - designed to maintain adequate protein/nitrogen excretion - requires intrarenal Renin/AnglI (RAS) activation. Thus, AIM 2 will test the hypothesis that Body-Size Excess relative to reduced nephron number - developing during rapid catch-up growth - induces the hemodynamic and RAS abnormalities in adult LPO. SubAims will test whether prevention of body size excess (by caloric restriction to maintain body wt percentile at the neonatal level) prevents: 2A.
Based on these findings we postulate that the increase of plasma gammaMSH level with decreased POMC message expression in SHR HSD rats is due to melanocortin receptor (MCR) resistance to gammaMSH in the kidneys induced by HSD. This resistance subsequently leads to high levels of plasma gammaMSH and feedback suppression of POMC mRNA expression. Thus, the specific aims of this study are: 1) To examine the effect of dietary salt on renal MC3 receptor mRNA expression in the kidneys of SHR rats. 2) To examine the response of blood pressure, MC3 mRNA expression and rate of sodium (Na) excretion to exogenous gammaMSH in SHR rats when fed a high salt diet.
The first specific hypothesis is that the aging process with the accompanying loss of estrogen activity is associated with a down regulation of the nitric oxide system resulting in hypertension. To test this hypothesis, Specific Aim 1 of this study is to monitor blood pressure and the level of activation of the NO system in intact, ovariectomized (OVX), and OVX+estrogen-treated Dahl salt sensitive and Dahl salt-resistant (R) female rats as they age from 3 month to 2022 months of age. The second specific hypothesis is that the factors maintaining the hypertension associated with the loss of estrogen activity in Dahl S rats is determined by the level of salt intake.
Aldosterone - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications